D.J.K. is in the Department of Pathology and J.D.K. is in the Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA. kenan001@mc.duke.edu or keene001@mc.duke.edu
Two structural studies of the La lupus antigen reveal that the La motif adopts a winged-helix fold at the N terminus and associates with the central RNA-recognition motif to form a binding surface for precursor transcripts synthesized by RNA polymerase III.
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