The authors are in the Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, USA. andy.ellington@mail.utexas.edu
A novel natural ribozyme has been discovered in the 5' noncoding region of the glmS mRNA. Surprisingly, glmS ribozyme activity is modulated by a cellular metabolite. The glmS ribozyme thus represents the first example of an novel regulatory mechanism in bacteria.
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