The author is in the Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA. bfp2@psu.edu
Like certain protein kinases, some protein acetyltransferases such as p300 may use an inhibitory loop that can be regulated to limit the accessibility of substrates to its active site. The finding that autoacetylation of this loop activates the acetyltransferase provides the first evidence for an acetylation cascade analogous to protein kinase cascades.
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