The author is in the Division of Biological Sciences, Section of Microbiology and Section of Molecular and Cellular Biology, and Center for Genetics and Development, University of California, Davis, California 95616-8665, USA. wdheyer@ucdavis.edu
BLM, the helicase implicated in Bloom's syndrome, and its yeast counterpart Sgs1 function in complexes with a type I topoisomerase to resolve double Holliday junctions to form non-crossover products. These data provide a direct explanation for the highly elevated sister chromatid exchange frequency in Bloom's syndrome cells.
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