1
A.E.J. is in the Department of Medical Biochemistry and Genetics and the Departments of Chemistry and of Biochemistry and Biophysics, Texas A&M University System Health Science Center, College Station, Texas 77843-1114, USA aejohnson@tamu.edu
2
R.E.J. is in the Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
The mechanism of transmembrane -barrel protein insertion into an intracellular membrane is essentially unknown. Two recent studies reveal that the process is protein-mediated and identify a protein complex that is involved.
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