Wobble during decoding: more than third-position promiscuity
Luisa Cochella
& Rachel Green
Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. ragreen@jhmi.edu
Structural studies by the Ramakrishnan and Agris groups allow us to directly observe how the ribosome's decoding site accommodates non-Watson-Crick base pairs in the third position of the codon-anticodon triplet while maintaining the one-amino-acid-per-codon framework that is central to life.
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