The authors are at the Skirball Institute of Biomolecular Medicine and Department of Pathology, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA.
roth@saturn.med.nyu.edu
Organisms such as yeast and humans are capable of both nonhomologous end joining (NHEJ) and homologous recombination (HR), but bacteria have typically been assumed to be capable only of HR. A recent study shows that mycobacteria accomplish NHEJ using just two proteins (homologs of the eukaryotic Ku and DNA ligase IV), whereas eukaryotes require many factors.
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