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Nature Structural & Molecular Biology  11, 1037 - 1043 (2004)
Published online: 2 November 2004; | doi:10.1038/nsmb851

Regulated nucleosome mobility and the histone code

Michael S Cosgrove1, Jef D Boeke2, 3 & Cynthia Wolberger1, 4

1  Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, 733 North Broadway Street, Baltimore, Maryland 21205, USA.

2  Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 733 North Broadway Street, Baltimore, Maryland 21205, USA.

3  High Throughput Biology Center, Johns Hopkins School of Medicine, 733 North Broadway Street, Baltimore, Maryland 21205, USA.

4  Howard Hughes Medical Institute, Johns Hopkins School of Medicine, 733 North Broadway Street, Baltimore, Maryland 21205, USA.

Correspondence should be addressed to Jef D Boeke jboeke@jhmi.edu
Post-translational modifications of the histone tails are correlated with distinct chromatin states that regulate access to DNA. Recent proteomic analyses have revealed several new modifications in the globular nucleosome core, many of which lie at the histone-DNA interface. We interpret these modifications in light of previously published data and propose a new and testable model for how cells implement the histone code by modulating nucleosome dynamics.

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Nature Structural & Molecular Biology
ISSN: 1545-9993
EISSN: 1545-9985
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