Another detour on the Toll road to the interferon antiviral response
John Hiscott
The author is at the Lady Davis Institute for Medical Research-Jewish General Hospital, Departments of Microbiology & Immunology, Medicine and Oncology, McGill University, Montreal, Canada, H3T 1E2. john.hiscott@Mcgill.ca
Recent characterization of two distinct signals leading to IRF-3 activation in response to double-stranded RNA recognition by Toll-like receptor 3 provides new mechanistic information on the regulatory events that link the detection of viral invasion by the cell with the development of the antiviral response.
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