The authors are at the Max F. Perutz Laboratories, University Departments of the Vienna Biocenter, Department of Microbiology and Genetics, University of Vienna, Dr. Bohrgasse 9/4, A-1030 Vienna, Austria. renee.schroeder@univie.ac.at
A second high-affinity binding site for the I-TevI homing endonuclease has been discovered. Surprisingly, the DNA sequence recognized is the protein's own operator; at this site, the endonuclease represses its own transcription instead of cleaving the DNA and inducing intron homing.
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