The authors are at the Department of Biochemistry, University of Utah, Salt Lake City, Utah 84132-3201, USA. chris@biochem.utah.edu
Ubiquitin-like proteins, including NEDD8, regulate a wide range of cellular processes and are mobilized by parallel biochemical pathways. A recent crystal structure explains how the NEDD8-specific E1 enzyme specifically recruits its cognate E2 enzyme by binding to a flexible N-terminal extension.
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