The authors are in the Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA. tedj@northwestern.edu
IgA triggers immune responses by binding to Fc receptors on cells of the immune system. The structure of IgA1-Fc in a complex with two molecules of FcRI provides clues that may explain the selectivity of IgA-mediated immune events.
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