Now, swing your partner! 3D-domain switching of WASP activates Arp2/3
complex
Sarah E Hitchcock-DeGregori
The author is in the Department of Neuroscience
and Cell Biology at Robert Wood Johnson Medical School, 675 Hoes
Lane, Piscataway, New Jersey 08854,
USA. hitchcoc@umdnj.edu
Structural and functional analysis of WASP family cell signaling
proteins shows that the same residues that are sequestered upon GTPase binding
in the autoinhibited state are involved in binding to and activating Arp2/3
complex, WASP's downstream partner in the signaling cascade.
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