Tao Wang and Daniel N. Hebert are in the Department of Biochemistry and Molecular Biology, Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Defective proteins in the endoplasmic reticulum (ER) are tagged as terminally aberrant by the composition of their N-linked glycans. The ER carbohydrate-binding protein EDEM selectively recognizes such tags and sorts the defective proteins for degradation via the ERAD pathway.
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REFERENCE Glycoproteins Nature Encyclopaedia of Life Sciences
