Andrew P. VanDemark and Christopher P. Hill are in the Department of Biochemistry, University of Utah School of Medicine, 20 N 1900 E, Room 211, Salt Lake City, Utah 84103 USA.
Covalent attachment of ubiquitin-like proteins to other proteins drives numerous important physiological processes. The recent structure of an ubiquitin-like E1 enzyme provides insight into the curious assembly line−like mechanism that initiates all ubiquitin-related protein processing pathways.
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