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Nature Structural Biology  10, 244 - 246 (2003)
doi:10.1038/nsb0403-244

Two-stepping with E1

Andrew P. VanDemark & Christopher P. Hill

Andrew P. VanDemark and Christopher P. Hill are in the Department of Biochemistry, University of Utah School of Medicine, 20 N 1900 E, Room 211, Salt Lake City, Utah 84103 USA.

Correspondence should be addressed to Christopher P. Hill chris@biochem.utah.edu
Covalent attachment of ubiquitin-like proteins to other proteins drives numerous important physiological processes. The recent structure of an ubiquitin-like E1 enzyme provides insight into the curious assembly line−like mechanism that initiates all ubiquitin-related protein processing pathways.

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Nature Structural & Molecular Biology
ISSN: 1545-9993
EISSN: 1545-9985
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