Co-translocational misfolding in the ER of living cells
Sheena E. Radford
Sheena E. Radford is in the School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK. s.e.radford@leeds.ac.uk
Recent experiments have shown that the co-translational folding of the multi-domain LDL receptor in the endoplasmic reticulum does not occur in a vectorial manner. Instead, newly translated chains form misfolded states involving incorrect disulfide bonds between residues distant in sequence.
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