The decline of induced transcription: a case of enzymatic symbiosis
Paolo Sassone-Corsi
Paolo Sassone-Corsi is in the Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue Laurent Fries, 67404 Illkirch, Strasbourg, France. paolosc@igbmc.u-strasbg.fr
CREB phosphorylation is required for transcriptional activation, but how dephosphorylation couples with decreased transcription activity was less obvious. New findings indicate that CREB can recruit histone deacetylase HDAC1 and protein phosphatase 1 in a concerted action, thus leading to attenuated transcription.
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