Annette Erbse, David A. Dougan and Bernd Bukau are in the Zentrum für Molekulare Biologie Heidelberg, University of Heidelberg, Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany.
In vivo selection improves the folding efficiency of the GroELS chaperone toward a specific substrate. Optimizing efficiency, however, comes at the price of narrowed substrate specificity.
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