The authors are in the Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544, USA. yshi@molbio.princeton.edu
In response to DNA double-strand breaks, histone H1.2 translocates from the nucleus into the cytoplasm, leading to the mitochondrial release of cytochrome c and subsequent apoptosis of the cell. The molecular underpinnings for these processes remain enigmatic.
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