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News and Views
Nature Structural Biology  10, 874 - 876 (2003)
doi:10.1038/nsb1103-874

The nuts and bolts of IRF structure

Aristidis Moustakas & Carl-Henrik Heldin

The authors are at the Ludwig Institute for Cancer Research, Box 595, SE-751 24 Uppsala, Sweden. Aris.Moustakas@LICR.uu.se or C-H.Heldin@LICR.uu.se

The new crystal structure of the IRF-3 transactivation domain reveals an evolutionarily conserved protein domain whose activity is modulated by phosphorylation controlling oligomerization and protein-protein interactions.

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Nature Structural & Molecular Biology
ISSN: 1545-9993
EISSN: 1545-9985
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