Elena Conti is in the Structural and Computational Biology Programme, EMBL, Meyerhofstrasse 1, Heidelberg D-69117, Germany. conti@embl-heidelberg.de
The hormone-related protein PTHrP travels from the cytosol to the nucleus by binding to the transport factor importin . Remarkably, the site of recognition of PTHrP is the N-terminal half of importin , which also has Ran-binding and nucleoporin-binding capabilities and is, therefore, sufficient by itself to function in PTHrP nuclear import.
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. Remarkably, the site of recognition of PTHrP is the N-terminal half of importin 
can migrate into the nucleus in an importin 
- and Ran-independent manner
