A multicenter prospective trial has investigated whether oral antibiotic treatment is as effective at minimizing renal scarring as sequential intravenous(IV)/oral therapy in infants and children with pyelonephritis. 171 children aged 1–36 months with a first episode of pyelonephritis received either oral cefixime for 10 days or IV ceftriaxone for 4 days followed by oral cefixime for 6 days. Follow-up scintigraphy showed renal scarring in 30.8% of children in the oral treatment group, but in only 27.3% of the sequential group. This finding supports the use of oral therapy for primary episodes of pyelonephritis in young children and infants.
ORIGINAL RESEARCH PAPER
Bocquet, N. et al. Randomized trial of oral versus sequential IV/oral antibiotic for pyelonephritis in children. Pediatrics doi:10.1542/peds.2011-0814
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Oral or sequential IV/oral antibiotics for pyelonephritis. Nat Rev Urol 9, 120 (2012). https://doi.org/10.1038/nrurol.2012.23
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DOI: https://doi.org/10.1038/nrurol.2012.23