Neoadjuvant targeted therapy can be used in patients with unresectable locally advanced, locally recurrent or metastatic renal cell carcinoma to induce cytoreduction before surgical resection. The efficacy of this multimodal therapy is still unproven, however, and must be balanced against a potential higher risk of perioperative complications.
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Ficarra, V., Novara, G. Neoadjuvant targeted therapies in renal cell carcinoma. Nat Rev Urol 7, 63–64 (2010). https://doi.org/10.1038/nrurol.2010.2
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DOI: https://doi.org/10.1038/nrurol.2010.2
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