Table of contents
August 2006 Volume 3 No 8
Editorial
Viewpoints
Treatment of high-risk, non-muscle-invasive bladder cancer
398For patients with high-risk superficial bladder cancer, accurate identification of tumor grade and stage, and appropriate treatment are paramount to achieving durable disease control and long-term survival. In this article, the author highlights the important issues relating to the management of this disease.
Penile rehabilitation after radical prostatectomy
400Erectile dysfunction is common following radical prostatectomy for localized prostate cancer, but there are indications that early pharmacological intervention could promote return of erectile function. The authors discuss preliminary results with postoperative prophylactic erectile therapy, the rationale behind such an approach, and its potential role in clinical practice.
Research Highlights
The 3IQ test is an accurate and simple way to classify incontinence
402Peyronie's disease is unlikely to resolve spontaneously
402Multiple DVIU attempts are not cost-effective for treating short urethral strictures
402A comparison of treatment strategies for stage T4 prostate cancer
403First nomograms proposed for survival of penile squamous cell carcinoma
403Favorable interim results for 'inside–out' transobturator vaginal tape procedure for SUI
404Most off-label drug prescribing is unsupported by scientific evidence
404The role of frozen-section analysis in nerve-sparing radical prostatectomy
405Is retroperitoneal laparoscopic heminephrectomy beneficial in infants?
405Support for oral kinase inhibitor therapy in cytokine-refractory metastatic RCC
406Accuracy of depression evaluation in hemodialysis patients
407Practice Points
Adjuvant bicalutamide for early prostate cancer: an update
408Understanding the natural treated history of chronic prostatitis/chronic pelvic pain syndrome
410Is nephron-sparing surgery for small renal masses underused?
412Long-term outcomes of the distal urethral polypropylene sling procedure for stress urinary incontinence
414doi:10.1038/ncpuro0522 | Full Text | PDF (100K)
What good or harm comes from prophylactic antibiotics in children with vesicoureteral reflux?
416What is the prognostic impact of positive surgical margins in surgically treated prostate cancer?
418doi:10.1038/ncpuro0549 | Full Text | PDF (100K)
Saw palmetto for benign prostatic hyperplasia: just how effective is it?
420doi:10.1038/ncpuro0553 | Full Text | PDF (101K)
Reviews
Finasteride as a chemopreventive agent in prostate cancer: impact of the PCPT on urologic practice
422The results of the Prostate Cancer Prevention Trial (PCPT) sparked a debate surrounding the advantages and disadvantages of using the 5-alpha reductase inhibitor finasteride as a chemoprevantative agent against prostate cancer. Over three years after the publication of the PCPT results there is still a reluctance to recommend the use of finasteride in this setting. This Review examines the PCPT data and discusses its results in light of further studies.
doi:10.1038/ncpuro0574 | Full Text | PDF (188K)
Mechanisms of Disease: late-onset hypogonadism
430As men age, physiological changes take place that can result in late-onset hypogonadism. A number of comorbid conditions are thought to be implicated in the endocrinological changes associated with aging, but their role is yet to be determined. In this Review the authors discuss the pathophysiological mechanisms behind late-onset hypogonadism and age-related endocrinological changes in men.
doi:10.1038/ncpuro0560 | Full Text | PDF (195K)
Primer: using decision analysis to improve clinical decision making in urology
439Deciding on a particular treatment can be difficult when a patient is presented with a range of therapies, each with their own associated chances of cure and risks of adverse effects. Decision analysis provides a more formal way of quantifying the benefits and harms associated with different treatments, which can be helpful in treatment decision making. This Primer Review provides a thorough overview of decision analysis and how it can be incorporated into clinical practice.
doi:10.1038/ncpuro0556 | Full Text | PDF (236K)
Case Study
Discussing quality-of-life issues with a patient newly diagnosed with prostate cancer
449doi:10.1038/ncpuro0562 | Full Text | PDF (121K)
