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Treatment of Peyronie's disease with oral pentoxifylline

Nature Clinical Practice Urology volume 3, pages 111–115 (2006)Cite this article

Abstract

Background A 51-year-old male presented with a penile deformity without obvious etiology. Physical examination revealed hard plaques in the dorsal and ventral penis.

Investigations Physical examination, penile ultrasound.

Diagnosis Peyronie's disease.

Management Oral pentoxifylline.

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Figure 1: Penile ultrasound showing areas of calcification within the plaques at the time of presentation.
Figure 2: Penile ultrasound showing areas of calcification within the plaques at the time of presentation (different cross-section from Figure 1).
Figure 3: Penile ultrasound showing resolution of the calcification within the dorsal plaque after 2 years of pentoxifylline treatment.

References

  1. Schwarzer U et al. (2001) The prevalence of Peyronie's disease: results of a large survey. BJU Int 88: 727–730

    Article  CAS  Google Scholar 

  2. Mulhall JP et al. (2004) Subjective and objective analysis of the prevalence of Peyronie's disease in a population of men presenting for prostate cancer screening. J Urol 171: 2350–2353

    Article  Google Scholar 

  3. Gholami SS et al. (2002) Peyronie's disease: a review. J Urol 169: 1234–1241

    Article  Google Scholar 

  4. Williams JL and Thomas GG (1970) The natural history of Peyronie's disease. J Urol 103: 75–76

    Article  CAS  Google Scholar 

  5. Gelbard MK et al. (1990) The natural history of Peyronie's disease. J Urol 144: 1376–1379

    Article  CAS  Google Scholar 

  6. Zargooshi J (2004) Trauma as the cause of Peyronie's disease: penile fracture as a model of trauma. J Urol 172: 186–188

    Article  Google Scholar 

  7. Levine LA and Greenfield JM (2003) Establishing a standardized evaluation of the man with Peyronie's disease. Int J Impot Res 15 (Suppl): S103–S112

    Article  Google Scholar 

  8. Hauck EW et al. (2003) Diagnostic value of magnetic resonance imaging in Peyronie's disease: a comparison both with palpation and ultrasound in the evaluation of plaque formation. Eur Urol 43: 293–300

    Article  Google Scholar 

  9. Chiao TB and Lee AJ (2005) Role of pentoxifylline and vitamin E in attenuation of radiation-induced fibrosis. Ann Pharmacother 39: 516–522

    Article  CAS  Google Scholar 

  10. Delanian S et al. (2005) Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis. J Clin Oncol 22: 1–10

    Google Scholar 

  11. Haddad P et al. (2005) Pentoxifylline and vitamin E combination for superficial radiation-induced fibrosis: a phase II clinical trial. Radiother Oncol 77: 324–326

    Article  CAS  Google Scholar 

  12. Hille A et al. (2005) Effect of pentoxifylline and tocopherol on radiation proctitis/enteritis. Strahlenther Onkol 181: 606–614

    Article  Google Scholar 

  13. Adams LA et al. (2004) A pilot trial of pentoxifylline in nonalcoholic steatohepatitis. Am J Gastroenterol 99: 2365–2368

    Article  CAS  Google Scholar 

  14. Georges C et al. (2004) Case report: resolution of symptomatic epidural fibrosis following treatment with combined pentoxifylline–tocopherol. Br J Radiol 77: 885–887

    Article  CAS  Google Scholar 

  15. Delanian S and Lefaix JL (2002) Complete healing of severe osteoradionecrosis with treatment combining pentoxifylline, tocopherol and clodronate. Br J Radiol 75: 467–469

    Article  CAS  Google Scholar 

  16. Valente EG et al. (2003) L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie's fibrotic plaque and related fibroblast cultures. Nitric Oxide 9: 229–244

    Article  CAS  Google Scholar 

  17. Videla S et al. Selective inhibition of phosphodiesterase-4 ameliorates chronic colitis and prevents intestinal fibrosis. J Pharmacol Exp Ther, in press

  18. Gumus B et al. (2004) Histopathological effects of sildenafil citrate on rat corpus cavernosum. Acta Histochem 106: 37–45

    Article  CAS  Google Scholar 

  19. Schwartz EJ et al. (2004) Sildenafil preserves intracorporeal smooth muscle after radical retropubic prostatectomy. J Urol 171: 771–774

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Clinical Fellow in Neurourology and Erectile Dysfunction,

    William O Brant & Tom F Lue

  2. Vice Chair, Emil Tanagho Endowed Chair in Clinical Urology and the Medical Director of the Knuppe Molecular Urology Laboratory, at the University of California, San Francisco, CA, USA

    William O Brant & Tom F Lue

  3. the Director of Andrology and Residency Director at the Walter Reed Army Medical Center Urology Service, Washington, DC, USA

    Robert C Dean

Authors
  1. William O Brant
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  2. Robert C Dean
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  3. Tom F Lue
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Corresponding author

Correspondence to Tom F Lue.

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Competing interests

The authors declare no competing financial interests.

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Brant, W., Dean, R. & Lue, T. Treatment of Peyronie's disease with oral pentoxifylline. Nat Rev Urol 3, 111–115 (2006). https://doi.org/10.1038/ncpuro0409

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