In a rat model of atherosclerosis-induced chronic bladder ischaemia, bladder overactivity could be improved by human amniotic-fluid-derived stem cell (hAFSC) treatment. Following arterial balloon endothelial injury of the common iliac artery, adult female rats received intravenous hAFSC treatment for 1, 3, or 7 days, or no treatment. In comparison with the nontreated group, bladder overactivity (consisting of decreased voided volumes and intercontraction intervals, and increased residual volumes), was improved at 8 weeks in the treated rats. The therapy might act via downregulation of oxidative stress and tumour necrosis factor expression.
References
Liang, C.-C. et al. Amniotic fluid stem cells ameliorate bladder dysfunction induced by chronic bladder ischemia in rat. Neurourol. Urodyn. http://dx.doi.org/10.1002/nau.23316 (2017)
Rights and permissions
About this article
Cite this article
Thoma, C. Stem cell therapy for chronic bladder ischaemia. Nat Rev Urol 14, 516 (2017). https://doi.org/10.1038/nrurol.2017.109
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrurol.2017.109