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Urothelial carcinoma

The value of extended lymphadenectomy during radical surgery for UTUC

The prognostic value of lymph node yield on oncological outcomes after radical nephroureterectomy with lymph node dissection in patients with upper tract urothelial carcinomas is unclear. Careful consideration and dedicated research of why, how and for whom lymph node dissection is appropriate are imperative to ensure improvements in patient survival.

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References

  1. Rouprêt, M. et al. European Association of Urology guidelines on upper urinary tract urothelial cell carcinoma: 2015 update. Eur. Urol. 68, 868–879 (2015).

    Article  Google Scholar 

  2. Winer, A. G. et al. Prognostic value of lymph node yield during nephroureterectomy for upper tract urothelial carcinoma. Urol. Oncol. http://dx.doi.org/10.1016/j.urolonc.2016.11.002 (2016).

  3. Abouassaly, R. et al. Troubling outcomes from population-level analysis of surgery for upper tract urothelial carcinoma. Urology 76, 895–901 (2010).

    Article  Google Scholar 

  4. Kondo, T. et al. Template-based lymphadenectomy in urothelial carcinoma of the renal pelvis: a prospective study. Int. J. Urol. 21, 453–459 (2014).

    Article  Google Scholar 

  5. Roscigno, M. et al. The extent of lymphadenectomy seems to be associated with better survival in patients with nonmetastatic upper-tract urothelial carcinoma: how many lymph nodes should be removed? Eur. Urol. 56, 512–518 (2009).

    Article  Google Scholar 

  6. Seisen, T. et al. Contemporary role of lymph node dissection at the time of radical nephroureterectomy for upper tract urothelial carcinoma. World J. Urol. http://dx.doi.org/10.1007/s00345-016-1764-z (2016).

  7. Bolenz, C. et al. Risk stratification of patients with nodal involvement in upper tract urothelial carcinoma: value of lymph-node density. BJU Int. 103, 302–306 (2009).

    Article  Google Scholar 

  8. Xylinas, E. et al. Prediction of true nodal status in patients with pathological lymph node negative upper tract urothelial carcinoma at radical nephroureterectomy. J. Urol. 189, 468–473 (2013).

    Article  Google Scholar 

  9. Davies, J. D. et al. Anatomic basis for lymph node counts as measure of lymph node dissection extent: a cadaveric study. Urology 81, 358–363 (2013).

    Article  Google Scholar 

  10. Abe, T. et al. Outcome of regional lymphadenectomy in accordance with primary tumor location on laparoscopic nephroureterectomy for urothelial carcinoma of the upper urinary tract: a prospective study. J. Endourol. 29, 304–309 (2015).

    Article  Google Scholar 

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Correspondence to Morgan Rouprêt.

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Rouprêt, M. The value of extended lymphadenectomy during radical surgery for UTUC. Nat Rev Urol 14, 136–138 (2017). https://doi.org/10.1038/nrurol.2017.9

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