A new publication finds that varicocele repair might improve semen quality enough to enable couples who are awaiting in vitro fertilization or intrauterine insemination to attempt natural conception or less-invasive assisted reproductive techniques. The approach is interesting because it seeks to establish varicocele treatment as one step in a multimodal path to parenthood.
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References
Jensen, C. F. S. et al. Varicocele and male infertility. Nat. Rev. Urol. 14, 523–533 (2017).
Evers, J. L., Collins, J. A. & Vandekerckhove, P. Surgery or embolisation for varicocele in subfertile men. Cochrane Database Syst. Rev. 1, CD000479 (2001).
Kroese, A. C., de Lange, N. M., Collins, J. & Evers, J. L. Surgery or embolization for varicoceles in subfertile men. Cochrane Database Syst. Rev. 10, CD000479 (2012).
Baazeem, A. et al. Varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair. Eur. Urol. 60, 796–808 (2011).
Abdel-Meguid, T. A., Al-Sayyad, A., Tayib, A. & Farsi, H. M. Does varicocele repair improve male infertility? An evidence-based perspective from a randomized, controlled trial. Eur. Urol. 59, 455–461 (2011).
Samplaski, M. K., Lo, K. C., Grober, E. D., Zini, A. & Jarvi, K. A. Varicocelectomy to “upgrade” semen quality to allow couples to use less invasive forms of assisted reproductive technology. Fertil. Steril. 108, 609–612 (2017).
Hurtado de Catalfo, G. E., Ranieri-Casilla, A., Marra, F. A., de Alaniz, M. J. & Marra, C. A. Oxidative stress biomarkers and hormonal profile in human patients undergoing varicocelectomy. Int. J. Androl. 30, 519–530 (2007).
Wang, Y. J., Zhang, R. Q., Lin, Y. J., Zhang, R. G. & Zhang, W. L. Relationship between varicocele and sperm DNA damage and the effect of varicocele repair: a meta-analysis. Reprod. Biomed. Online 25, 307–314 (2012).
Kirby, E. W., Wiener, L. E., Rajanahally, S., Crowell, K. & Coward, R. M. Undergoing varicocele repair before assisted reproduction improves pregnancy rate and live birth rate in azoospermic and oligospermic men with a varicocele: a systematic review and meta-analysis. Fertil. Steril. 106, 1338–1343 (2016).
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Fode, M. Varicocele repair in the era of assisted reproductive technology. Nat Rev Urol 14, 705–706 (2017). https://doi.org/10.1038/nrurol.2017.182
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DOI: https://doi.org/10.1038/nrurol.2017.182
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