Negative pathology on urethral frozen section during radical cystectomy is a reliable indicator that urethrectomy is not necessary. Results of 298 patients' urethral frozen sections were compared with rereviewed samples and the final urethral margins. All negative sections were confirmed to be negative, resulting in a negative predictive value of 100%. Of 28 sections that were originally positive, two were determined to be negative, resulting in a positive predictive value of 93%. The study authors recommend that positive urethral frozen sections are discussed at the time of surgery in order to make real-time decisions on the need for urethrectomy.
References
Kates, M. et al. Accuracy of urethral frozen section during radical cystectomy for bladder cancer. Urol. Oncol. http://dx.doi.org/10.1016/j.urolonc.2016.06.014 (2016)
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Fenner, A. Accuracy of urethral frozen section. Nat Rev Urol 13, 495 (2016). https://doi.org/10.1038/nrurol.2016.144
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DOI: https://doi.org/10.1038/nrurol.2016.144
