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Unique genetic determinants of human kidney development

Human kidneys have many features in common with those of other species, but also unique properties. A detailed human–mouse comparison of the genetic programme governing early events in nephron formation has revealed interspecies differences that could explain how nephron number in adult kidneys is determined.

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References

  1. Vize, P. D. & Smith, H. W. A. Homeric view of kidney evolution: a reprint of H. W. Smith's classic essay with a new introduction. Anat. Rec. A Discov. Mol. Cell Evol. Biol. 277, 344–354 (2004).

    Article  PubMed  Google Scholar 

  2. Brenner, B. M., Garcia, D. L. & Anderson, S. Glomeruli and blood pressure: less of one, more the other? Am. J. Hypertens. 1, 335–347 (1988).

    Article  CAS  PubMed  Google Scholar 

  3. Bertram, J. F., Douglas-Denton, R. N., Diouf, B., Hughson, M. D. & Hoy, W. E. Human nephron number: implications for health and disease. Pediatr. Nephrol. 26, 1529–1533 (2011).

    PubMed  Google Scholar 

  4. Cebrian, C., Asai, N., D'Agati, V. & Costantini, F. The number of fetal nephron progenitor cells limits ureteric branching and adult nephron endowment. Cell Rep. 7, 127–137 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Schuchardt, A., D'Agati, V., Pachnis, V. & Costantini, F. Renal agenesis and hypodysplasia in ret-k mutant mice result from defects in ureteric bud development. Development 122, 1919–1929 (1996).

    CAS  PubMed  Google Scholar 

  6. O'Brien, L. L. et al. Differential regulation of mouse and human nephron progenitors by the Six family of transcriptional regulators. Development 143, 595–608 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Xu, P. X. The EYA-SO/SIX complex in development and disease. Pediatr. Nephrol. 28, 843–854 (2013).

    Article  PubMed  Google Scholar 

  8. Senanayake, U. et al. The pluripotent renal stem cell regulator SIX2 is activated in renal neoplasms and influences cellular proliferation and migration. Hum. Pathol. 44, 336–345 (2013).

    Article  CAS  PubMed  Google Scholar 

Download references

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Correspondence to Leif Oxburgh.

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Oxburgh, L. Unique genetic determinants of human kidney development. Nat Rev Urol 13, 304–305 (2016). https://doi.org/10.1038/nrurol.2016.87

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