Nature Reviews Urology

Volume 14, No 7 July 2017

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Comment


TRACERx Renal: tracking renal cancer evolution through therapy

Samra Turajlic and Charles Swanton for TRACERx Renal consortium


Intratumour heterogeneity is a critical driver of cancer progression and treatment failure. TRACERx Renal is a prospective study that aims to define the evolutionary trajectories of renal cancer in space and time through multiregion and longitudinal tumour sampling.

Front cover of the current issue of Nature Reviews Urology

2016 2-year Impact Factor 7.735 Journal Metrics 2-year Median 5

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Perspective

Science and society: Development of the Asian Men's Health Report: challenges and opportunities

Chirk Jenn Ng, Chin Hai Teo, Christopher Chee Kong Ho and Hui Meng Tan

In this Perspective, Ng and colleagues detail the development of the Asian Men's Health Report (AMHR), detailing challenges faced during its creation. Men's health reports can support the development of men's health policies and the AMHR can be used as to guide for the production of men's health reports and to promote men's health globally.

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Review

Telomeres and telomerase in prostate cancer development and therapy

Mindy Kim Graham & Alan Meeker


Aberrations in telomere biology occur in prostate cancer tumorigenesis and progression. Graham and Meeker review the role of shortened telomeres in prostate tumour pathogenesis, including genomic instability and mutations. They describe the clinical utility of assessment of telomere dysfunction and the therapeutic potential of treatments targeting telomerase and telomeres.

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Perspective


Landmarks in the treatment of muscle-invasive bladder cancer


Niyati Lobo, Chloe Mount, Kawa Omar, Rajesh Nair, Ramesh Thurairaja & Muhammad Shamim Khan

Muscle-invasive bladder cancer (MIBC) is an aggressive disease associated with high morbidity and mortality. In this Perspective, the authors describe the timeline of advances in treating MIBC, including radical cystectomy with pelvic lymph node dissection, the creation of increasingly sophisticated urinary diversions, use of cisplatin-based neoadjuvant chemotherapy, bladder-sparing protocols, and immunotherapy.

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The Movember Collection - In partnership with The Movember Foundation


Nature Reviews Urology is proud to present the Movember Collection in partnership with the Movember Foundation.

The collection is based around themes from the Global Action Plan (GAP) consortia. GAP is a worldwide collaboration between researchers in prostate and testicular cancer, funded by Movember. Launched in 2011, the scheme connects researchers around the globe, improving data and knowledge sharing, and optimising the use of research funding. Movember currently is funding five GAP programmes: Biomarkers (GAP1), Imaging (GAP2), Active Surveillance (GAP3), Exercise and Metabolic Health (GAP4), and Testicular Cancer (GAP5). GAP6, focussing on oligometastatic prostate cancer, has recently been announced.

Our 2017 cover image

Cover image supplied by Sudeh Izadmehr, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. The image shows a high-power fluorescence microscopy view of a FVB/N mouse prostate. Immunofluorescence staining was performed using DAPI (4',6-diamidino-2-phenylindole) to stain nuclei and monoclonal antibody against α-smooth muscle actin to identify smooth muscle cells. Smooth muscle cells are elongated, tapering at each end with a centrally located nucleus. They encircle the basal epithelial, luminal epithelial, and neuroendocrine cells of each prostate gland. In prostate adenocarcinoma, breaks appear in the perimeter of circumferential smooth muscle cells; this discontinuity is a marker of invasion.

The Men's Health Collection—in partnership with the Movember Foundation

To celebrate our partnership with Movember, the editors of Nature Reviews Urology have put together a special collection of articles by key opinion leaders, which highlights issues important to men, their families, and their physicians in the areas of prostate cancer, BPH, fertility, and testosterone deficiency.

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