Nature Reviews Urology

Volume 14, No 5 May 2017


Consensus Statement

Expert consensus document: Semantics in active surveillance for men with localized prostate cancer – results of a modified Delphi consensus procedure

Sophie M. Bruinsma et al. and Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance (GAP3) consortium

Semantic heterogeneity exists regarding terminology for active surveillance (AS) for prostate cancer. A panel of leading specialists in prostate cancer and AS involved in the Movember Foundation's Global Action Plan Prostate Cancer Active Surveillance (GAP3) consortium participated in a consensus-forming project to reach international consensus on definitions of terms related to this management option. This standard terminology could support multidisciplinary communication, reduce the extent of variations in clinical practice and optimize clinical decision making.

Front cover of the current issue of Nature Reviews Urology

2015 2-year Impact Factor 5.957 Journal Metrics 2-year Median 4



Patient-derived xenografts as in vivo models for research in urological malignancies

Takahiro Inoue, Naoki Terada, Takashi Kobayashi and Osamu Ogawa

Patient-derived xenograft (PDX) models can maintain the original histology and the molecular and genetic characteristics of the source tumour. Thus, PDX models have advantages over conventional models for drug development and treatment decisions in personalized medicine. In this Review, the authors discuss the potential of PDX models for both basic and clinical urological research.

Advance Online Publication


Oxidative stress and male infertility

Shilpa Bisht, Muneeb Faiq, Madhuri Tolahunase and Rima Dada

High levels of seminal oxidative stress lead to sperm DNA damage and male factor infertility. In this review, the authors describe the mechanisms of oxidative-stress-induced male factor infertility, and how lifestyle-related interventions might reduce levels of seminal oxidative stress, ameliorate infertility and potentially improve the health of the children of men with high levels of seminal oxidative stress.

Advance Online Publication


An overview of female-to-male gender-confirming surgery

Shane D. Morrison, Mang L. Chen and Curtis N. Crane

Gender transition can substantially improve quality-of-life in individuals with gender dysphoria, and various surgical options are available for female-to-male (FtM) transition, including facial and chest masculinization, body contouring, and genital surgery. In this Review, the authors describe the management of these patients, with a particular emphasis on the surgical techniques used, and consider developments that might improve outcomes for FtM patients in the future.


The Movember Collection - In partnership with The Movember Foundation

Nature Reviews Urology is proud to present the Movember Collection in partnership with the Movember Foundation.

The collection is based around themes from the Global Action Plan (GAP) consortia. GAP is a worldwide collaboration between researchers in prostate and testicular cancer, funded by Movember. Launched in 2011, the scheme connects researchers around the globe, improving data and knowledge sharing, and optimising the use of research funding. Movember currently is funding five GAP programmes: Biomarkers (GAP1), Imaging (GAP2), Active Surveillance (GAP3), Exercise and Metabolic Health (GAP4), and Testicular Cancer (GAP5). GAP6, focussing on oligometastatic prostate cancer, has recently been announced.

Our 2017 cover image

Cover image supplied by Sudeh Izadmehr, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. The image shows a high-power fluorescence microscopy view of a FVB/N mouse prostate. Immunofluorescence staining was performed using DAPI (4',6-diamidino-2-phenylindole) to stain nuclei and monoclonal antibody against α-smooth muscle actin to identify smooth muscle cells. Smooth muscle cells are elongated, tapering at each end with a centrally located nucleus. They encircle the basal epithelial, luminal epithelial, and neuroendocrine cells of each prostate gland. In prostate adenocarcinoma, breaks appear in the perimeter of circumferential smooth muscle cells; this discontinuity is a marker of invasion.

The Men's Health Collection—in partnership with the Movember Foundation

To celebrate our partnership with Movember, the editors of Nature Reviews Urology have put together a special collection of articles by key opinion leaders, which highlights issues important to men, their families, and their physicians in the areas of prostate cancer, BPH, fertility, and testosterone deficiency.

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