Nature Reviews Urology 6, 345 (2009). doi:10.1038/nrurol.2009.116
Author: Suzanne J. Farley
]]>Nature Reviews Urology 6, 346 (2009). doi:10.1038/nrurol.2009.114
Author: Sarah Payton
]]>Nature Reviews Urology 6, 346 (2009). doi:10.1038/nrurol.2009.121
Prostate cancerDecreasing the duration of androgen suppression in locally advanced prostate cancer compromises patient survival. Interim analysis of data from a trial in which 970 men were randomized to radiotherapy plus either short-term or long-term androgen suppression has shown that cessation of hormone therapy
]]>Nature Reviews Urology 6, 347 (2009). doi:10.1038/nrurol.2009.112
Author: Kathryn Senior
]]>Nature Reviews Urology 6, 347 (2009). doi:10.1038/nrurol.2009.120
Author: Lisa Richards
]]>Nature Reviews Urology 6, 347 (2009). doi:10.1038/nrurol.2009.71
Author: Kathryn Senior
]]>Nature Reviews Urology 6, 348 (2009). doi:10.1038/nrurol.2009.115
Author: Lisa Richards
]]>Nature Reviews Urology 6, 348 (2009). doi:10.1038/nrurol.2009.117
Author: Lisa Richards
]]>Nature Reviews Urology 6, 349 (2009). doi:10.1038/nrurol.2009.118
Author: Nick Groves-Kirkby
]]>Nature Reviews Urology 6, 349 (2009). doi:10.1038/nrurol.2009.122
SurgeryThe rate at which registrars attain proficiency in laparoscopic surgery is markedly enhanced by training with a virtual reality simulator. Skills equivalent to an experience level of 20–50 laparoscopic salpingectomies were obtained by the 11 predominantly female gynecology/obstetrics trainees randomized to the virtual reality
]]>Nature Reviews Urology 6, 350 (2009). doi:10.1038/nrurol.2009.113
Author: Lisa Richards
]]>Nature Reviews Urology 6, 350 (2009). doi:10.1038/nrurol.2009.119
Author: Kathryn Senior
]]>Nature Reviews Urology 6, 350 (2009). doi:10.1038/nrurol.2009.128
Author: Barrie R. Cassileth, Jyothirmai Gubili & K. Simon Yeung
]]>Nature Reviews Urology 6, 351 (2009). doi:10.1038/nrurol.2009.111
Author: Christopher R. Chapple
Antimuscarinic drugs are the first-line treatment for overactive bladder. However, traditional formulations are associated with a number of adverse effects, most notably dry mouth. A study comparing a new topical gel formulation of oxybutynin to placebo has confirmed its efficacy and tolerability for treating overactive bladder.
]]>Nature Reviews Urology 6, 352 (2009). doi:10.1038/nrurol.2009.109
Authors: Tariq F. Al-Shaiji & Gerald B. Brock
Emerging data indicate that outcomes of surgical procedures are improved if surgery is performed in high-volume hospitals or by high-volume surgeons. This principle seems to hold true for penile prosthesis surgery, but careful consideration is necessary before adopting a 'center of excellence' model for this, or any, procedure.
]]>Nature Reviews Urology 6, 354 (2009). doi:10.1038/nrurol.2009.104
Authors: Jay B. Shah & Vitaly Margulis
Retrospective analyses of single-institution experiences are difficult to generalize to the population as a whole. The emerging trend of utilizing national datasets and disease registries provides information relatable to the average patient that may prove considerably more useful to community urologists.
]]>Nature Reviews Urology 6, 355 (2009). doi:10.1038/nrurol.2009.106
Authors: Hendrik Isbarn & Pierre I. Karakiewicz
An algorithm used to evaluate risk in patients with prostate cancer has been improved by taking into account the quantity of risk factors present. The adapted scheme accurately predicts disease-specific mortality, and reveals that prostate cancer is the major cause of death in patients with three or more risk factors.
]]>Nature Reviews Urology 6, 357 (2009). doi:10.1038/nrurol.2009.108
Author: Robert J. Klein
Genetic linkage has recently been reported between several genomic loci and a subtype of prostate cancer that contains a fusion between the genes TMPRSS2 and ERG. These data suggest an analytical approach that might improve future studies of the genetic cause of prostate and other cancers.
]]>Nature Reviews Urology 6, 358 (2009). doi:10.1038/nrurol.2009.105
Author: Noel W. Clarke
A new guideline from the US has neatly summarized the evidence regarding the use of 5α-reductase inhibitors for prostate disease, but falls short of providing definitive management recommendations. It will, however, be a valuable aid to both patients and physicians in the clinical decision-making process.
]]>Nature Reviews Urology 6, 360 (2009). doi:10.1038/nrurol.2009.110
Author: Katsuto Shinohara
The importance of prostate biopsy is undisputed, but the procedure can be excruciatingly painful for some men. Does combined anesthesia aimed at addressing the two sources of pain associated with transrectal ultrasound-guided prostate biopsy provide a more effective form of pain relief than either modality alone?
]]>Nature Reviews Urology 6, 361 (2009). doi:10.1038/nrurol.2009.107
Authors: Steven L. Chang & Mark L. Gonzalgo
Greater surgeon experience is associated with lower recurrence rates following laparoscopic radical prostatectomy for prostate cancer. A new study shows that the learning curve for this procedure is slower than that for open surgery, and highlights the challenges of developing the unique skills that are required to master each technique.
]]>Nature Reviews Urology 6, 363 (2009). doi:10.1038/nrurol.2009.100
Authors: Milton D. Gross, Melvyn Korobkin, Wessam Bou Assaly, Ben Dwamena & Mehdi Djekidel
The incidental discovery of adrenal masses during modern diagnostic imaging is a common occurrence. These masses form part of a long differential diagnostic list; most often, they are benign adrenal adenomas, but their discovery requires a clinical evaluation that is sufficiently broad to exclude clinically
]]>Nature Reviews Urology 6, 375 (2009). doi:10.1038/nrurol.2009.102
Authors: E. Jason Abel & Christopher G. Wood
Metastatic renal cell carcinoma (RCC) has traditionally been associated with a poor prognosis with few effective treatments. In the multimodal treatment of metastatic RCC, cytoreductive nephrectomy (CN) became the standard of care after two randomized trials demonstrated a benefit in overall survival in patients who
]]>Nature Reviews Urology 6, 384 (2009). doi:10.1038/nrurol.2009.123
Authors: David Ulmert, M. Frank O'Brien, Anders S. Bjartell & Hans Lilja
The kallikrein, prostate-specific antigen (PSA), is one of the world's most frequently used disease biomarkers. After almost two decades of research and clinical experience, the diagnostic and monitoring limitations of PSA are beginning to be understood. Most physicians are aware of PSA's low specificity for
]]>Nature Reviews Urology 6, 392 (2009). doi:10.1038/nrurol.2009.101
Authors: Emil Lou, Jeremy Goodwin, David N. Howell, John Hicks & L. Brett Caram
Background. A 57-year-old African American man presented to a tertiary care center with a 6-month history of fatigue and worsening abdominal pain. He had lost 9.1 kg in weight in the 3 months leading up to presentation, and described subjective fevers and night sweats
]]>Nature Reviews Urology 6, 398 (2009). doi:10.1038/nrurol.2009.98
Authors: Muhammad I. Aslam, Philippa Cheetham & Marek A. W. Miller
The presence of blood in the semen—hematospermia—is an anxiety-provoking but usually self-limiting condition. Its exact incidence remains unclear. The risk of underlying malignancy, despite being very low, drives evaluation. There is confusion amongst clinicians as to how best to refer, evaluate and treat men with
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