Featured: Labiaplasty: motivation, techniques, and ethics

Özer and colleagues discuss our current knowledge of labiaplasty including motivation for and management of the request for surgery and surgical techniques and outcomes.

Latest Reviews

  • Review |

    In this Review, Lotti and Maggi discuss the correlations between sexual dysfunction and male infertility, focusing on the associations between reproductive, sexual, psychological, and general health.

    • Francesco Lotti
    •  & Mario Maggi
  • Consensus Statement | | open

    The International Society of Paediatric Oncology–Renal Tumour Study Group (SIOP–RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP–RTSG 2016 (the UMBRELLA protocol). In this Consensus Statement, members of the SIOP–RTSG outline the rationale for the recommendations for treatment of CCSK in the protocol.

    • Saskia L. Gooskens
    • , Norbert Graf
    • , Rhoikos Furtwängler
    • , Filippo Spreafico
    • , Christophe Bergeron
    • , Gema L. Ramírez-Villar
    • , Jan Godzinski
    • , Christian Rübe
    • , Geert O. Janssens
    • , Gordan M. Vujanic
    • , Ivo Leuschner
    • , Aurore Coulomb-L'Hermine
    • , Anne M. Smets
    • , Beatriz de Camargo
    • , Sara Stoneham
    • , Harm van Tinteren
    • , Kathy Pritchard-Jones
    • , Marry M. van den Heuvel-Eibrink
    •  & on behalf of the International Society of Paediatric Oncology–Renal Tumour Study Group (SIOP–RTSG)
  • Review |

    Genomic aberrations of the PTEN tumour suppressor are among the most common in prostate cancer. In this Review, the authors describe the roles of PTEN, consider how PTEN status could act as a potential prognostic and predictive biomarker, and discuss the potential of PTEN and its downstream pathways as a therapeutic target.

    • Tamara Jamaspishvili
    • , David M. Berman
    • , Ashley E. Ross
    • , Howard I. Scher
    • , Angelo M. De Marzo
    • , Jeremy A. Squire
    •  & Tamara L. Lotan
  • Review |

    Neuroendocrine prostate cancers (NEPCs) are androgen independent and aggressive and have characteristics of epithelial–mesenchymal plasticity and stem-like cell properties. This Review describes the link between lineage plasticity and an emergent NEPC phenotype and how this knowledge can aid in the development of novel therapeutics.

    • Alastair H. Davies
    • , Himisha Beltran
    •  & Amina Zoubeidi
  • Review |

    Clinical conditions that cause poor bladder compliance, reduced capacity, and incontinence can require bladder augmentation or use of regenerative techniques and scaffolds. Replicating an organ that is under frequent mechanical loading and unloading needs particular attention to its biomechanical requirements. In this Review, the authors describe the biomechanics of the bladder and discuss how different scaffolds and techniques can be assessed to determine the best possible approach to bladder augmentation.

    • Fatemeh Ajalloueian
    • , Greg Lemon
    • , Jöns Hilborn
    • , Ioannis S. Chronakis
    •  & Magdalena Fossum
  • Review |

    Lee and Gujar review the potential of virotherapy to increase the effectiveness of immunotherapies in prostate cancer. They discuss how oncolytic viruses can improve anticancer immunological responses and strategies for combining virotherapy with other immunotherapies to obtain improved patient outcomes.

    • Patrick Lee
    •  & Shashi Gujar

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