Featured: WNT signalling in prostate cancer

Murillo-Garzón and Kypta discuss the role of the WNT pathway in prostate tumours and the tumour microenvironment

Latest Reviews

  • Review |

    In this Review, the authors describe the role of the NO–sGC–cGMP signalling pathway in disease pathophysiology of urogenital tissue. They discuss advances in directly targeting sGC to enhance cGMP production independently using NO-independent stimulators and activators of sGC and the potential of these molecules for treating urogenital disorders.

    • Fabiola Z. Mónica
    •  & Edson Antunes
  • Review |

    In this Review, Woldu and colleagues describe the implications of Rho GTPase signalling aberrations in the development of malignancy, including urothelial carcinoma. This signalling pathway has the potential for therapeutic targeting in this disease, but much work is necessary before current laboratory-based research can be translated into the clinic.

    • Solomon L. Woldu
    • , Ryan C. Hutchinson
    • , Laura-Maria Krabbe
    • , Oner Sanli
    •  & Vitaly Margulis
  • Review |

    Many emerging opportunities exist for microfluidics in male infertility diagnosis and treatment, and promising microfluidic approaches are under investigation for addressing male infertility. In this Review, the authors describe and discuss these approaches for sperm analysis and selection.

    • Reza Nosrati
    • , Percival J. Graham
    • , Biao Zhang
    • , Jason Riordon
    • , Alexander Lagunov
    • , Thomas G. Hannam
    • , Carlos Escobedo
    • , Keith Jarvi
    •  & David Sinton
  • Consensus Statement | | open

    The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP–RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP–RTSG 2016 (the UMBRELLA protocol). In this Consensus Statement, members of SIOP–RTSG outline the rationale for the recommendations in the protocol.

    • Marry M. van den Heuvel-Eibrink
    • , Janna A. Hol
    • , Kathy Pritchard-Jones
    • , Harm van Tinteren
    • , Rhoikos Furtwängler
    • , Arnauld C. Verschuur
    • , Gordan M. Vujanic
    • , Ivo Leuschner
    • , Jesper Brok
    • , Christian Rübe
    • , Anne M. Smets
    • , Geert O. Janssens
    • , Jan Godzinski
    • , Gema L. Ramírez-Villar
    • , Beatriz de Camargo
    • , Heidi Segers
    • , Paola Collini
    • , Manfred Gessler
    • , Christophe Bergeron
    • , Filippo Spreafico
    • , Norbert Graf
    •  & on behalf of the International Society of Paediatric Oncology — Renal Tumour Study Group (SIOP–RTSG)
  • Review |

    Sfanos et al. discuss the potentially procarcinogenic role of prostatic infections and inflammation in prostate pathogenesis. They summarize findings that suggest that an aberrant microbiome together with an inflammatory microenvironment are involved in the initiation of prostate cancer precursor lesions.

    • Karen S. Sfanos
    • , Srinivasan Yegnasubramanian
    • , William G. Nelson
    •  & Angelo M. De Marzo

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