Testing for the level of complement C4d on erythrocytes and on B cells, alongside ELISAs for anti-dsDNA antibodies and antinuclear antibodies, provides an index score with 80% sensitivity for systemic lupus erythematosus (SLE). In a multicentre study that enrolled 210 patients with SLE, 178 people with other rheumatic diseases and 205 healthy controls, the specificity for SLE of this score was 87%.
ORIGINAL RESEARCH PAPER
Kalunian, K. C. et al. Measurements of cell bound complement activation products enhance diagnostic performance in systemic lupus erythematosus. Arthritis Rheum. doi:10.1002/art.34669
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An assay panel for the diagnosis of SLE. Nat Rev Rheumatol 8, 562 (2012). https://doi.org/10.1038/nrrheum.2012.163
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DOI: https://doi.org/10.1038/nrrheum.2012.163