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Genetics

Mutations in the IL1RN locus lead to autoinflammation

Nature Reviews Rheumatology volume 5, pages 480–482 (2009)Cite this article

The results of two new studies suggest mutations in the gene encoding the interleukin (IL)-1 receptor antagonist (IL-1Ra) are responsible for a spectrum of childhood inflammatory disorders characterized by an imbalance in IL-1 expression. What implications do these intriguing results have for the diagnosis and management of IL1-driven inflammatory disorders?

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Figure 1: Competitive inhibition of the activities of IL-1 by IL-1Ra.

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Authors and Affiliations

  1. Division of Rheumatology, University Hospitals of Geneva, Geneva, Switzerland

    Cem Gabay

  2. Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland

    Gaby Palmer

Authors
  1. Cem Gabay
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  2. Gaby Palmer
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Correspondence to Gaby Palmer.

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The authors declare no competing financial interests.

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Gabay, C., Palmer, G. Mutations in the IL1RN locus lead to autoinflammation. Nat Rev Rheumatol 5, 480–482 (2009). https://doi.org/10.1038/nrrheum.2009.177

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