FIGURE 2 | Regulators of MSC differentiation.

From the following article:

Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis

Ichiro Takada, Alexander P. Kouzmenko & Shigeaki Kato

Nature Reviews Rheumatology 5, 442-447 (August 2009)

doi:10.1038/nrrheum.2009.137

Wnt and PPAR|[gamma]| signaling in osteoblastogenesis and adipogenesis

MSCs are pluripotent cells capable of differentiating into cells of functionally distinct lineages. A number of regulators control MSC lineage fate. Humoral factors like Wnt ligands, BMP and TGF-beta transmit their signals through cognate cell membrane receptors expressed by the differentiating cells. Transcription factors often govern the final cell lineage decision during MSC differentiation, and their transcriptional activities are modulated through crosstalk with cell-membrane receptor-mediated signals. Abbreviations: BMP, bone morphogenetic protein; C/EBP, CCAAT/enhancer binding protein; GLI, GLI family zinc finger; KLF, Kruppel-like factor; MSC, mesenchymal stem cell; MYF, myogenic factor; MyoD, myogenic differentiation 1; NR3C1, nuclear receptor subfamily 3, group C, member 1; PPARgamma, peroxisome proliferator-activated receptor gamma; RUNX2, runt-related transcription factor 2; SOX, sex determining region Y-box; SHH, sonic hedgehog homolog; SP7, Sp7 transcription factor (formerly known as osterix); TGF-beta, transforming growth factor beta; WWTR1, WW domain containing transcription regulator 1 (formerly known as TAZ).

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