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Research Highlights
Nature Reviews Rheumatology 4, 388 (1 August 2008) | doi:10.1038/ncprheum0849
Bisphosphonates do not prevent ankylosis in a mouse model of spondyloarthritis
Abstract
Lories RJ et al. (2008) Inhibition of osteoclasts does not prevent joint ankylosis in a mouse model of spondyloarthritis. Rheumatology (Oxford) 47: 605–608 A current hypothesis of the pathogenesis of spondyloarthritis—that inflammation and tissue damage triggers an exaggerated repair response—is being challenged.
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