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Nature Reviews Rheumatology 4, 394–395 (1 August 2008) | doi:10.1038/ncprheum0845

Does early growth hormone therapy prevent glucocorticoid-associated growth retardation in children with JIA?

Lisa G Rider & Ellen W Leschek

Simon D et al. (2007) Early recombinant human growth hormone treatment in glucocorticoid-treated children with juvenile idiopathic arthritis: a 3-year randomized study. J Clin Endocrinol Metab 92: 2567–2573 Synopsis Background Glucocorticoid therapy is associated with decreased growth; however, studies have shown that growth hormone (GH) treatment can restore growth in children with juvenile idiopathic arthritis (JIA) after serious glucocorticoid-induced growth effects have developed.