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Do elevated red blood cell methotrexate polyglutamate levels predict methotrexate efficacy?

Nature Clinical Practice Rheumatology volume 3, pages 256–257 (2007)Cite this article

boxed-textDervieux T et al. (2006) Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis. Arthritis Rheum 54: 3095–3103

Red blood cell levels of methotrexate polyglutamates might predict methotrexate responders

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References

  1. Dervieux T et al. (2004) Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum 50: 2766–2774

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  2. Weisman MH et al. (2006) Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis. Arthritis Rheum 54: 607–612

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  3. Dervieux T et al. (2005) Pharmacogenetic and metabolite measurements are associated with clinical status in patients with rheumatoid arthritis treated with methotrexate: results of a multicentred cross sectional observational study. Ann Rheum Dis 64: 1180–1185

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Acknowledgements

The synopsis was written by Rosalind Archer, Editorial Assistant, Nature Clinical Practice.

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  1. Division of Clinical Pharmacology and Rheumatology, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA cronsb01@mcrcr6.med.nyu.edu

Authors and Affiliations

  1. Pathology and Pharmacology in the Divisions of Clinical Pharmacology and Rheumatology, in the Department of Medicine, BN Cronstein is a Professor of Medicine, New York University School of Medicine, New York, NY, USA.,

    Bruce N Cronstein

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  1. Bruce N Cronstein
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Competing interests

The author has received research grants from the following companies: Amgen, Bristol–Myers Squibb, Can-Fite Biopharma, Cellzome, Endocyte, Honorarial Speakers' Bureaus, King Pharmaceutical, Prometheus Laboratories, Regeneron, Sepracor, Tap Pharmaceuticals.

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Cronstein, B. Do elevated red blood cell methotrexate polyglutamate levels predict methotrexate efficacy?. Nat Rev Rheumatol 3, 256–257 (2007). https://doi.org/10.1038/ncprheum0475

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