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Nature Reviews Rheumatology 3, 694–695 (1 December 2007) | doi:10.1038/ncprheum0650

Proton-pump inhibitors as a protective treatment for high-risk patients receiving treatment with NSAIDs

Francis KL Chan

Vonkeman HE et al. (2007) Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case–control study. Arthritis Res Ther 9: R52 Synopsis Background Gastrointestinal complications are the main concern of NSAID treatment in patients with rheumatic diseases.