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Nature Reviews Rheumatology 2, 246–247 (1 May 2006) | doi:10.1038/ncprheum0177

Rheumatoid arthritis|[mdash]|is methotrexate re-employment an effective treatment option?

Joel M Kremer

Kapral T et al. (2006) Methotrexate in rheumatoid arthritis is frequently effective, even if re-employed after a previous failure. Arthritis Res Ther 8: R46–R55 Synopsis Background Disease-modifying antirheumatic drugs (DMARDs) are one of the most common therapeutic agent types used in the treatment of rheumatoid arthritis (RA).