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Research Highlights
Nature Reviews Rheumatology 2, 640 (1 December 2006) | doi:10.1038/ncprheum0323
Ethnic variation in MTHFR polymorphisms in patients with RA
Abstract
Hughes LB et al. (2006) Racial or ethnic differences in allele frequencies of single-nucleotide polymorphisms in the methylenetetrahydrofolate reductase gene and their influence on response to methotrexate in rheumatoid arthritis. Ann Rheum Dis 65: 1213–1218 Methylenetetrahydrofolate reductase (MTHFR) has an important role in folate metabolism, and could affect a patient's response to the antifolate drug methotrexate.
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