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Nature Reviews Rheumatology 2, 648–649 (1 December 2006) | doi:10.1038/ncprheum0353

Do genetic variations in the adenosine pathway affect patient response to methotrexate?

Bruce N Cronstein

Wessels JAM et al. (2006) Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis. Arthritis Rheum 54: 2830–2839 Synopsis Background Methotrexate is commonly used to treat patients with rheumatoid arthritis (RA), and has been shown to be most effective when therapy is initiated in early disease.