Researchers have developed a new method for measuring knee joint effusion-synovitis volume, an MRI marker of synovial inflammation. This new approach gave reproducible volume measurements that were highly correlated with effusion-synovitis scores. In patients with symptomatic knee osteoarthritis who had low baseline levels of vitamin D and effusion-synovitis (n = 413), monthly supplementation with vitamin D3 (50,000 IU) over 24 months retarded the progression of effusion-synovitis compared with the placebo group (−1.94 ml, 95% CI −3.54 to −0.33).
References
Wang, X. et al. Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis. Osteoarthritis Cartilage http://dx.doi.org/10.1016/j.joca.2017.02.804 (2017)
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McHugh, J. A new tool for measuring synovial inflammation. Nat Rev Rheumatol 13, 258 (2017). https://doi.org/10.1038/nrrheum.2017.46
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DOI: https://doi.org/10.1038/nrrheum.2017.46
