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T follicular helper cells and the gut microbiome in arthritis

Nature Reviews Rheumatology volume 13, pages 72–74 (2017)Cite this article

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Rheumatoid arthritis is associated with an expansion of certain gut commensals, although the underlying mechanism remains unknown. In 2016, studies using experimental models of arthritis have begun to unravel the links between the gut microbiota, T follicular helper cells and arthritis.

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Figure 1: Gut microbial diversity in an individual determines the differentiation of T cells into TH17 or TFH cells.

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Acknowledgements

V. T. is supported by grants from the US Department of Defense, NIH and the Mayo Clinic Center of Individualized Medicine.

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  1. Department of Immunology and Rheumatology, Mayo Clinic, 200 First Street SW, Rochester, 55905, Minnesota, USA

    Veena Taneja

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  1. Veena Taneja
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Correspondence to Veena Taneja.

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Taneja, V. T follicular helper cells and the gut microbiome in arthritis. Nat Rev Rheumatol 13, 72–74 (2017). https://doi.org/10.1038/nrrheum.2016.222

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