Tissue engineers use mesenchymal stem cells (MSCs) and scaffolds for the regenerative treatment of injured or degenerated musculoskeletal tissues. As MSC interactions with state-of-the-art natural biological scaffolds are complex, the choice of a specific candidate for clinical applications based on interactions with MSCs in vitro, or even in vivo, is challenging.
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References
Beitzel, K. et al. Properties of biologic scaffolds and their response to mesenchymal stem cells. Arthroscopy 30, 289–298 (2014).
Ringe, J., Burmester, G. R. & Sittinger, M. Regenerative medicine in rheumatic disease-progress in tissue engineering. Nat. Rev. Rheumatol. 8, 493–498 (2012).
Shahab-Osterloh, S. et al. Mesenchymal stem cell-dependent formation of heterotopic tendon-bone insertions (osteotendinous junctions). Stem Cells 28, 1590–1601 (2010).
Zhang, Q. & Cheng, B. Tendon-derived stem cells as a new cell source for tendon tissue engineering. Front. Biosci. (Landmark Ed.) 18, 756–764 (2013).
Beitzel, K. et al. The future role of mesenchymal stem cells in the management of shoulder disorders. Arthroscopy 29, 1702–1711 (2013).
Isaac, C., Gharaibeh, B., Witt, M., Wright, V. J. & Huard, J. Biologic approaches to enhance rotator cuff healing after injury. J. Shoulder Elbow Surg. 21, 181–190 (2012).
Sittinger, M., Hutmacher, D. W. & Risbud, M. V. Current strategies for cell delivery in cartilage and bone regeneration. Curr. Opin. Biotechnol. 15, 411–418 (2004).
Ricchetti, E. T., Aurora, A., Iannotti, J. P. & Derwin, K. A. Scaffold devices for rotator cuff repair. J. Shoulder Elbow Surg. 21, 251–265 (2012).
Pan, J. et al. Rotator cuff repair using a decellularized tendon slices graft: an in vivo study in a rabbit model. Knee Surg. Sports Traumatol. Arthrosc. http://dx.doi.org/10.1007/s00167-014-2923-7.
Turner, N. J. & Badylak, S. F. Biologic scaffolds for musculotendinous tissue repair. Eur. Cell. Mater. 25, 130–143 (2013).
Acknowledgements
The authors are supported by the Bundesministerium für Bildung und Forschung (Grant: BCRT 1315848A).
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M.S. declares that he is a shareholder of BioRetis and CellServe, and that he is a consultant for BioTissue Technologies. He is cofounder of the companies BioRetis, CellServe and TransTissue Technologies. J.R. declares no competing interests.
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Ringe, J., Sittinger, M. Selecting the right biological scaffold for tissue engineering. Nat Rev Rheumatol 10, 388–389 (2014). https://doi.org/10.1038/nrrheum.2014.79
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DOI: https://doi.org/10.1038/nrrheum.2014.79
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