Biological samples contain multiple types of extracellular vesicles.
Extracellular vesicles contribute to inflammation.
Extracellular vesicles in the inflamed joint.
Department of Genetics, Cell and Immunobiology, Semmelweis University, Nagyvárad tér 4, H-1089 Budapest, Hungary.
- Edit I. Buzas,
- Bence György &
- András Falus
Department of Rheumatology, Polyclinic of the Hospitaller Brothers of St John of God, Frankel Leó út 54, H-1023 Budapest, Hungary.
- György Nagy
Centre for Experimental Rheumatology, Clinic of Rheumatology, University Hospital, Gloriastrasse 25, Zürich CH-8091, Switzerland.
- Steffen Gay
E.I.B. and B.G. researched the data for the article, substantially contributed to discussion of the article and wrote the article. E.I.B., G.N., A.F. and S.G. contributed to reviewing and editing of the manuscript before submission.
Competing interests statement
The authors declare no competing interests.
Edit I. Buzas
Edit Buzas MD, PhD, DSc is the Professor and Chairman of the Department of Genetics, Cell and Immunobiology, Semmelweis University. Previously she worked at the Debrecen Medical University, Hungary, the McGill University, Montreal, Canada and the Rush Medical Centre, Chicago, USA. Her earlier research focused on autoimmunity, rheumatoid arthritis, experimental models of arthritis and glycobiology. With her team she has been working in the field of extracellular vesicles since 2006. She is the Associate Editor of the Journal of Extracellular Vesicles and a board member of the Exosomes and Microvesicles, and WG leader of the European Network on Microvesicles and Exosomes in Health and Disease.
Bence György MD, PhD, is a postdoctoral Researcher in the Department of Neurology and Program in Neuroscience, Massachusetts General Hospital and Harvard Medical School, Boston, MA. Bence György graduated from the Semmelweis University, Faculty of Medicine and then finished his PhD in Immunology and Genetics under the supervision of Prof. Edit Buzas. He is now working at the Department of Neurology, Massachusetts General Hospital in Boston, MA, under the mentorship of Prof. Xandra Breakefield. His main research interest is developing novel gene delivery vehicles to target the eye and the central nervous system.
György Nagy MD, PhD, med habil is a consultant rheumatologist and immunologist in the Semmelweis University, Budapest. He is Council Member of the European Society for Clinical Investigation, and Member of the Faculty 1000 Rheumatology/Clinical Immunology Board. His research interest is studying the role of microvesicles in autoimmunity and investigating the mechanism of T cell activation in autoimmune diseases.
Andras Falus (born 1947), PhD, DSc, med. habil is Professor of Immunology and Genetics in the Dept. Genetics, Cell and Immunobiology, Semmelweis University, Budapest. He is a member of the Hungarian Academy of Sciences and Academia Europeae, a former President of the Hungarian Society of Immunology, founder of the Hungarian Biobanking system and a member of the Henry Kunkel Society, Rockefeller University, NY. He is also the founder Editor of Immunome Research, Editor of Inflammation Research and European Editor of International Immunology, and a board member of Autoimmunity and Cellular Molecular Life Sciences. His interests are immunogenomics, histamine biology, oncogenomics, and systems biology. Peer reviewed journal articles: 396, books: 8, book chapters: 23, H index: 40.
Steffen Gay MD has been a Professor at the Centre of Experimental Rheumatology at the University Hospital in Zurich, Switzerland since 1996. Prof. Gay started his scientific career as a student and young MD at the Institute of Pathology at the University of Leipzig, Germany. He then served as Researcher in connective tissue research at the Max Planck Institute for Biochemistry in Martinsried/Munich, Germany and spent more than 20 years doing medical and dental research at the University of Alabama at Birmingham in the United States. Current interest focuses on the epigenetic regulation of gene expression by acetylation, methylation, sumoylation and microRNAs in health and diseases.