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Nature Reviews Rheumatology 1, 67–68 (1 December 2005) | doi:10.1038/ncprheum0025

Recombinant osteoprotegerin suppresses bone resorption in juvenile Paget's disease

Rachel Murphy

Cundy T et al. (2005) Recombinant osteoprotegerin for juvenile Paget's disease. N Engl J Med 353: 918–923 Juvenile Paget's disease results from a mutation in the gene encoding osteoprotegerin, a protein that inhibits bone-resorbing osteoclast cells.